The New i-DReC Analysis Method

LabSolutions Q&A

The New i-DReC Analysis Method

What Is i-DReC? – An Introduction Through Application Examples –

When analyzing high-concentration samples, have you experienced cases where you were unable to obtain the peak area because the chromatogram exceeded the measurement limits of the detector (saturation)?

Here, we introduce the i-DReC (Intelligent Dynamic Range Extension Calculator), which extends the dynamic range and solves this problem.
The figures below show examples of indomethacin calibration curves that include high-concentration calibration points.

Calibration Curve for Indomethacin Samples Containing High-Concentration Calibration Points (Without i-DReC)

Calibration Curve for Indomethacin Samples Containing High-Concentration Calibration Points (With i-DReC)

  Measurement in High-Concentration Range (Concentration 400 mg/L min.) Dilution of High-Concentration Sample
Existing Method
Linearity cannot be maintained and area value cannot be calculated correctly. Required
Using i-DReC
Maintains linearity and correctly calculates area value! Not required!

 Advantage of i-DReC in Creating Calibration Curves

Quantitation Using Area Percentages

i-DReC is effective even in cases where you want to quantify trace impurities and the main components simultaneously. The figures below show examples of quantitative analyses of impurities by area percentages.

   Number of Analyses Area Value and Concentration Correction by Dilution Procedure and Dilution Rate
Existing Method
 2 runs (main components and impurities)  Required
Using i-DReC
 1 run to complete analysis!  Not required!
Advantages of i-DReC When Quantifying Impurities

 

 

Top of This Page